Jun 25, 2020 · The presence of LV thrombus presents an increased risk of systemic thromboembolism including stroke in around 10–15% of patients in the absence of anticoagulation. 6 In patients with LV thrombus after acute myocardial infarction, most thromboembolic events occur within the first 4 months, 7 whilst in most cases, thrombus is no longer visible ...
Rationale: Left ventricular non-compaction cardiomyopathy (LVNC) is a rare heart disorder related to thrombosis.Anticoagulant therapy is suggested for the treatment of this disease. The success of the novel oral anticoagulant rivaroxaban as a treatment option for this disorder is unclear.
Introduction. Rivaroxaban is an oral factor Xa inhibitor and it is approved for prevention of stroke in non-valvular atrial fibrillation (AF) patients .Chagas disease is common in Brazil and it leads to congestive heart failure; 37% of the patients also have apical aneurysm and 11% have intraventricular thrombus, leading to stroke or systemic embolism risk of 4.4% per year , .
Learning Objectives • Patients with severe LV systolic dysfunction and history of LV thrombus should be continued on anticoagulation for life to prevent recurrent LV thrombus formation and systemic thromboembolism. • Rivaroxaban should not be used in liver cirrhosis patients, as drug metabolism, thrombin, von Willebrand factor, and albumin levels are altered in liver disease.
In a prospective study rivaroxaban for lv thrombus of left atrial appendage thrombi, treatment with rivaroxaban was associated with a 41.5% rate of thrombus resolution. 24 However, there was no direct comparison with warfarin. It is also possible that different classes of DOACs, and even individual agents, possess differing levels of effectiveness for treatment of LV ...
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